Exploring CYP450 Pathways in Functional Sympatholysis

In this episode of The APS Publications Podcast, coauthors Alexander A. Buelow and J. Mikhail Kellawan discuss their recent study, "Inhibition of CYP450 pathways reduces functional sympatholysis in healthy young adults," published in AJP–Regulatory, Integrative and Comparative Physiology.

They explore how functional sympatholysis, which has traditionally been considered independent of nitric oxide and prostaglandins, may actually involve endothelial CYP450 pathways. Their findings show that inhibition of CYP450-2C9 reduces sympatholytic responses during dynamic handgrip exercise combined with lower body negative pressure. This suggests that CYP450 plays an important role in regulating blood flow during exercise in healthy individuals.

Tune in for insights into vascular physiology, research methodology, and the broader implications of these findings for cardiovascular research.

 

Inhibition of CYP450 pathways reduces functional sympatholysis in healthy young adults

Alexander A. Buelow, Jacob E. Matney, Sarah M. Skillett, John D. Ashley, Jiwon Song, Chris Mixon, Amir Akbari Fakhrabadi, Matthew Stanford, Debra A. Bemben, Daniel J. Larson, and J. Mikhail Kellawan

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2025 328:6, R642-R650