Exploring Epinephrine's Role in EPO Gene Activation During Hypoxia

In this episode of The APS Publications Podcast, featuring AJP-Regulatory, Integrative and Comparative Physiology, coauthors Xiaoyu Su and Nanduri R. Prabhakar dive into their recently published research titled "Adrenal Epinephrine Facilitates Erythropoietin Gene Activation by Hypoxia Through β2 Adrenergic Receptor Interaction with Hif-2α." The study explores the role of sympathetic nervous system (SNS) activation in erythropoietin (EPO) gene expression during hypobaric hypoxia, shedding light on how adrenal epinephrine, via β2 adrenergic receptors, interacts with the transcription factor HIF-2α to enhance EPO gene activation. Tune in as they highlight the breakthrough findings that deepen our understanding of the physiological mechanisms underlying hypoxia-induced gene regulation.

 

Adrenal epinephrine facilitates erythropoietin gene activation by hypoxia through β2 adrenergic receptor interaction with Hif-2α

Xiaoyu Su, Matthew Hildreth, Srikar Rapaka, Ying-Jie Peng, Jayasri Nanduri, and Nanduri R. Prabhakar

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2025 328:1, R75-R80