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Listen to author interviews, commentaries from thought leaders, and insightful discussions about important topics in physiology and scientific publishing. Brought to you by the American Physiological Society (APS) Publications.
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Friday Jun 28, 2024
Friday Jun 28, 2024
In this APS Publications Podcast, Sarah Commodore delves into a study titled "Lung proinflammatory microRNA and cytokine expression in a mouse model of allergic inflammation: role of sex chromosome complement and gonadal hormones." This research explores how microRNAs (miRNAs), which are crucial in gene regulation and environmental interactions, might contribute to sex differences in allergic responses and lung diseases.
The study employed a targeted omics approach to examine how gonadal hormones and chromosomal components influence lung responses to allergen exposure. The findings suggest that sex hormones play a significant role in regulating miRNA expression and proinflammatory markers during allergic airway inflammation. This indicates a complex interplay between genetic (sex chromosome complement) and hormonal factors in shaping immune responses in the lungs.
Physiological Genomics 2024 56:2, 179-193