Predictive modeling of maternal mRNA stability

In this episode of The APS Publications Podcast, Keith E. Latham, discusses the recently published manuscript titled "Predictive modeling of oocyte maternal mRNA features for five mammalian species reveals potential shared and species-restricted regulators during maturation."

 

NEW & NOTEWORTHY Conservation across species of mRNA features regulating maternal mRNA stability during mammalian oocyte maturation was analyzed. 3′-Untranslated region length and synonymous codon usage are positively associated with stability, while GC content is negatively associated. Just three RNA binding protein motifs were predicted to regulate mRNA stability across all five species examined, but associated pathways and functions are shared, indicating oocytes of different species arrive at comparable physiological destinations via different routes.

 

Peter Z. Schall and Keith E. Latham Predictive modeling of oocyte maternal mRNA features for five mammalian species reveals potential shared and species-restricted regulators during maturation Physiological Genomics Published December 19, 2023. DOI: 10.1152/physiolgenomics.00048.2023