Uncovering Heightened Cardiovascular Reflexes in Chronic Kidney Disease

In this episode of The APS Publications Podcast, corresponding author Han-Kyul Kim provides an overview of the study titled "Exercise pressor reflex function is augmented in rats with chronic kidney disease," recently published in AJP–Regulatory, Integrative and Comparative Physiology. Dr. Kim discusses how the research team uncovered exaggerated blood pressure responses triggered by the exercise pressor reflex (EPR) in a chronic kidney disease (CKD) animal model. The study highlights how both the muscle mechanoreflex, activated through passive stretch and the muscle metaboreflex, stimulated by intra-arterial capsaicin, contribute to this hypertensive effect. Tune in to learn more about how sympathetic overactivation and altered reflex function could play a key role in cardiovascular risk for individuals with CKD.

 

Exercise pressor reflex function is augmented in rats with chronic kidney disease

Han-Kyul Kim, Juan A. Estrada, Ayumi Fukazawa, Amane Hori, Gary A. Iwamoto, Scott A. Smith, Masaki Mizuno, and Wanpen Vongpatanasin

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2025 328:4, R460-R469